IOX4 - 搜索结果 | AbMole中文官网

找到约 58 条 “IOX4” 相关结果（用时 0.068 秒）

目录号	产品名称	中文名称	靶点
M11006	IOX4	IOX4	HIF
	IOX4 是一种选择性 PHD2 抑制剂，IC50 值为 1.6 nM，在细胞和野生型小鼠中诱导 HIFα 表达，可通透血脑屏障。IOX4 与 PHD2 活性位点的 2-氧代戊二酸 (2OG) 竞争并置换。
M11621	ChemBridge-5112759	ChemBridge化合物-5112759	Screening Compounds and Building Blocks
	1-(2-furylmethylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one (5112759)
	ChemBridge特有类药化合物/先导化合物-5112759，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11629	ChemBridge-5114006	ChemBridge化合物-5114006	Screening Compounds and Building Blocks
	ethyl 3-(benzylamino)-2-(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-3-phenylacrylate (5114006)
	ChemBridge特有类药化合物/先导化合物-5114006，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11635	ChemBridge-5115807	ChemBridge化合物-5115807	Screening Compounds and Building Blocks
	5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone (5115807)
	ChemBridge特有类药化合物/先导化合物-5115807，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11641	ChemBridge-5118173	ChemBridge化合物-5118173	Screening Compounds and Building Blocks
	3-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)-2-isopropyl-1,3-oxazolidine (5118173)
	ChemBridge特有类药化合物/先导化合物-5118173，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11691	ChemBridge-5140203	ChemBridge化合物-5140203	Screening Compounds and Building Blocks
	4-nitrophenyl (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetate (5140203)
	ChemBridge特有类药化合物/先导化合物-5140203，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11692	ChemBridge-5140317	ChemBridge化合物-5140317	Screening Compounds and Building Blocks
	2-(5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)-3-methylbutanoic acid (5140317)
	ChemBridge特有类药化合物/先导化合物-5140317，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11693	ChemBridge-5140589	ChemBridge化合物-5140589	Screening Compounds and Building Blocks
	3-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-oxo-4H-chromen-7-yl hexopyranoside (5140589)
	ChemBridge特有类药化合物/先导化合物-5140589，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11697	ChemBridge-5141565	ChemBridge化合物-5141565	Screening Compounds and Building Blocks
	4-amino-1-[6-(hydroxymethyl)-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxathiol-4-yl]-2(1H)-pyrimidinone hydrochloride (5141565)
	ChemBridge特有类药化合物/先导化合物-5141565，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11710	ChemBridge-5143717	ChemBridge化合物-5143717	Screening Compounds and Building Blocks
	5-{[5-(2,5-dichlorophenyl)-2-furyl]methylene}-3-methyl-2-thioxo-1,3-thiazolidin-4-one (5143717)
	ChemBridge特有类药化合物/先导化合物-5143717，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11715	ChemBridge-5146442	ChemBridge化合物-5146442	Screening Compounds and Building Blocks
	2,2'-{(4,4'-dioxo-2,2'-dithioxo-5,5'-bi-1,3-thiazolidine-3,3'-diyl)bis[(1-oxo-3,1-propanediyl)imino]}dibenzoic acid (5146442)
	ChemBridge特有类药化合物/先导化合物-5146442，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11719	ChemBridge-5148440	ChemBridge化合物-5148440	Screening Compounds and Building Blocks
	5-(4-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (5148440)
	ChemBridge特有类药化合物/先导化合物-5148440，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11720	ChemBridge-5149378	ChemBridge化合物-5149378	Screening Compounds and Building Blocks
	N-(5-chloro-2-pyridinyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfonamide (5149378)
	ChemBridge特有类药化合物/先导化合物-5149378，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11721	ChemBridge-5149498	ChemBridge化合物-5149498	Screening Compounds and Building Blocks
	3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2-hydroxyphenyl)propanamide (5149498)
	ChemBridge特有类药化合物/先导化合物-5149498，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11723	ChemBridge-5149715	ChemBridge化合物-5149715	Screening Compounds and Building Blocks
	4-methyl-2-oxo-2H-chromen-7-yl {[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-4-oxo-4H-chromen-7-yl]oxy}acetate (5149715)
	ChemBridge特有类药化合物/先导化合物-5149715，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11745	ChemBridge-5158496	ChemBridge化合物-5158496	Screening Compounds and Building Blocks
	sodium 4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butanoate (5158496)
	ChemBridge特有类药化合物/先导化合物-5158496，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11746	ChemBridge-5158497	ChemBridge化合物-5158497	Screening Compounds and Building Blocks
	4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxybutanamide (5158497)
	ChemBridge特有类药化合物/先导化合物-5158497，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11748	ChemBridge-5158906	ChemBridge化合物-5158906	Screening Compounds and Building Blocks
	3-allyl-5-(2-furylmethylene)-2-thioxo-1,3-thiazolidin-4-one (5158906)
	ChemBridge特有类药化合物/先导化合物-5158906，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11751	ChemBridge-5161874	ChemBridge化合物-5161874	Screening Compounds and Building Blocks
	3-ethyl-5-(1-methyl-2(1H)-pyridinylidene)-2-thioxo-1,3-thiazolidin-4-one (5161874)
	ChemBridge特有类药化合物/先导化合物-5161874，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11752	ChemBridge-5162044	ChemBridge化合物-5162044	Screening Compounds and Building Blocks
	5-(2-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (5162044)
	ChemBridge特有类药化合物/先导化合物-5162044，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11757	ChemBridge-5170837	ChemBridge化合物-5170837	Screening Compounds and Building Blocks
	5-(3,4-dihydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one (5170837)
	ChemBridge特有类药化合物/先导化合物-5170837，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11758	ChemBridge-5171838	ChemBridge化合物-5171838	Screening Compounds and Building Blocks
	2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid -2-ethyl-3,9-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-4-amine (1:1) (5171838)
	ChemBridge特有类药化合物/先导化合物-5171838，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11789	ChemBridge-5186324	ChemBridge化合物-5186324	Screening Compounds and Building Blocks
	N-(4-bromophenyl)-2-(4-{[(4-bromophenyl)amino]carbonyl}phenyl)-1,3-dioxo-5-isoindolinecarboxamide (5186324)
	ChemBridge特有类药化合物/先导化合物-5186324，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11796	ChemBridge-5190839	ChemBridge化合物-5190839	Screening Compounds and Building Blocks
	1-({2-[2-(4-tert-butylphenyl)ethyl]-1,3-dioxolan-4-yl}methyl)piperidine (5190839)
	ChemBridge特有类药化合物/先导化合物-5190839，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11802	ChemBridge-5200824	ChemBridge化合物-5200824	Screening Compounds and Building Blocks
	5-(4-isopropylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one (5200824)
	ChemBridge特有类药化合物/先导化合物-5200824，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11809	ChemBridge-5210574	ChemBridge化合物-5210574	Screening Compounds and Building Blocks
	4-(4-{[2-(1-naphthyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]carbonyl}phenoxy)benzoic acid (5210574)
	ChemBridge特有类药化合物/先导化合物-5210574，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11822	ChemBridge-5212809	ChemBridge化合物-5212809	Screening Compounds and Building Blocks
	N-[3-(dimethylamino)-1,4-dioxo-1,4-dihydro-2-naphthalenyl]acetamide (5212809)
	ChemBridge特有类药化合物/先导化合物-5212809，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11840	ChemBridge-5217444	ChemBridge化合物-5217444	Screening Compounds and Building Blocks
	6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamide (5217444)
	ChemBridge特有类药化合物/先导化合物-5217444，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11855	ChemBridge-5225515	ChemBridge化合物-5225515	Screening Compounds and Building Blocks
	5-{[5-(4-bromophenyl)-2-furyl]methylene}-2-thioxo-1,3-thiazolidin-4-one (5225515)
	ChemBridge特有类药化合物/先导化合物-5225515，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M11863	ChemBridge-5228930	ChemBridge化合物-5228930	Screening Compounds and Building Blocks
	5-(2,3-dihydro-1,4-benzodioxin-2-yl)-4H-1,2,4-triazole-3-thiol (5228930)
	ChemBridge特有类药化合物/先导化合物-5228930，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。
M2134	Vortioxetine hydrobromide	溴酸沃替西汀；氢溴酸沃泰西汀；沃替西汀氢溴酸	5-HT Receptor
	Lu AA21004
	Vortioxetine (Lu AA21004) HBr是一种5-羟色胺抑制剂，抑制5-HT1A， 5-HT1B， 5-HT3A， 5-HT7受体和SERT，IC50分别为15 nM， 33 nM， 3.7 nM， 19 nM和1.6 nM。
M4943	3,4,5-Trimethoxyphenylacetic acid	3,4,5-Trimethoxyphenylacetic acid	Metabolite/Endogenous Metabolite
	Cell suspensions did not release carbon dioxide from 3,4-[methoxyl-14C]dihydroxy-5-methoxyphenylacetate but accumulated 1 mol of methanol per mol of 3,4,5-trimethoxyphenylacetate oxidized.
M6058	Vortioxetine	沃替西汀	5-HT Receptor
	Lu AA 21004
	Vortioxetine (沃替西汀; Lu AA21004) 对5-HT1A，5-HT1B，5-HT3A，5-HT7受体和SERT的IC50分别为15 nM，33 nM，3.7 nM，19 nM和1.6 nM。
M6831	IOX1	IOX1	Histone demethylase
	IOX-1
	IOX1是一个2OG oxygenases强效的广谱抑制剂，对KDM4A和KDM3A的IC50值分别为0.6 uM和0.1 uM。IOX1也抑制ALKBH5。
M43847	1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidine-4-carbaldehyde	1-[4-(2,6-二氧代-3-哌啶基)苯基]哌啶-4-甲醛	Ligand for E3 Ligase
	4-Piperidinecarboxaldehyde, 1-[4-(2,6-dioxo-3-piperidinyl)phenyl]-
	1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidine-4-carbaldehyde
M10799	BMS-986242	BMS-986242	IDO
	BMS-986242 是一种具有口服活性、强效和选择性的 indoleamine-2,3-dioxygenase 1 (IDO1) 抑制剂。BMS-986242 可用于癌症研究。
M16349	9β,13β-Epidioxyabiet-8(14)-en-18-oic acid	9β,13β-Epidioxyabiet-8(14)-en-18-oic acid	Diterpenoids
	9β,13β-Epidioxyabiet-8(14)-en-18-oic acid
M16895	2,3-Di(3',4'-methylenedioxybenzyl) -2-buten-4-olide	2,3-Di(3',4'-methylenedioxybenzyl) -2-buten-4-olide	Lignans
	2,3-Di(3',4'-methylenedioxybenzyl) -2-buten-4-olide
M16993	2-(2,2-Dimethyl-1,3-dioxolan -4-yl)propane-1,2-diol	2-(2,2-Dimethyl-1,3-dioxolan -4-yl)propane-1,2-diol	Others
	2-(2,2-Dimethyl-1,3-dioxolan -4-yl)propane-1,2-diol
M16994	1,6-Dioxaspiro[4.5]decan-2-methanol	1,6-Dioxaspiro[4.5]decan-2-methanol	Others
	1,6-Dioxaspiro[4.5]decan-2-methanol
M17947	Chol-8-en-24-oic acid, 7,15-dihydroxy-4,4,14-trimethyl-3,11-dioxo-, (5α)-	Chol-8-en-24-oic acid, 7,15-dihydroxy-4,4,14-trimethyl-3,11-dioxo-, (5α)-	Others
	7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid 是一种灵芝三萜类化合物（灵芝中重要的生物活性成分，可用于研究慢性肝病）。
M29484	IDO-IN-13	IDO-IN-13	IDO
	IDO-IN-13 是一种有效的 indoleamine 2,3-dioxygenase 1 (IDO1) 抑制剂，EC50 值为 17 nM，详细信息请参考 WO2019040102A1，example 43。
M43876	1,1-Dimethylethyl 6-(2,6-dioxo-3-piperidinyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate	1,1-Dimethylethyl 6-(2,6-dioxo-3-piperidinyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate	Ligand for E3 Ligase
	1,1-Dimethylethyl 6-(2,6-dioxo-3-piperidinyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate
M29809	NU223612	NU223612	PROTAC
	NU223612 是一种有效的 PROTAC (PROTACs)，可降解吲哚胺 2,3-双加氧酶 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO))，Kd 为 640 nM。NU223612 通过 CRBN 介导的蛋白酶体降解有效降解 IDO1 蛋白。NU223612 以 290 nM 的亲和力与 CRBN 结合。NU223612 可以穿过血脑屏障 (BBB)。
M31050	Rivanicline hemioxalate	Rivanicline hemioxalate	AChR/AChE
	RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate
	Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) 是神经元烟碱受体 (neuronal nicotinic receptor) 激动剂，对 α4β2 亚型有高度选择性，Ki 为 26 nM，而对 α7 受体的 Ki 则为3.6 μM。
M38771	1,4-Epidioxybisabola-2,10-dien-9-one	1,4-Epidioxybisabola-2,10-dien-9-one	Anti-infection
	1,4-Epidioxybisabola-2,10-dien-9-one 是 1,4-epidioxy-bisabola-2,12-diene 的衍生物，可从 Curcuma longa L. 中分离出来。1,4-Epidioxybisabola-2,10-dien-9-one 在 MDCK 细胞系中表现出抗流感病毒 A/PR/8/34 (H1N1) 的抗病毒活性，IC50 为 16.79 ± 4.03 μg/mL。
M40195	3,4-Methylenedioxycinnamic acid	3,4-Methylenedioxycinnamic acid	Others
	3,4-Methylenedioxycinnamic acid 是 phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA 连接酶的抑制剂。3,4-Methylenedioxycinnamic acid 会促进可溶性酚，尤其是香草酸的形成。
M41161	Helioxanthin	Helioxanthin	Anti-infection
	Helioxanthin (ACH126447) 具有体外抗病毒活性，对HBV的EC50为1 μM，还可抗黄病毒。
M41897	RTIOXA-43	RTIOXA-43	OX Receptor
	RTIOXA-43 是一种食欲素受体 (orexin receptor) 激动剂，对于 OX2 和 OX1 受体的 EC50 值均为 24 nM。
M43851	1-[5-(2,6-Dioxo-3-piperidinyl)-2-pyridinyl]-4-piperidineacetic acid	1-[5-(2,6-Dioxo-3-piperidinyl)-2-pyridinyl]-4-piperidineacetic acid	Ligand for E3 Ligase
	1-[5-(2,6-Dioxo-3-piperidinyl)-2-pyridinyl]-4-piperidineacetic acid
M43860	1-[5-(2,6-Dioxo-3-piperidinyl)-3-fluoro-2-pyridinyl]-4-piperidineacetic acid	1-[5-(2,6-Dioxo-3-piperidinyl)-3-fluoro-2-pyridinyl]-4-piperidineacetic acid	Ligand for E3 Ligase
	1-[5-(2,6-Dioxo-3-piperidinyl)-3-fluoro-2-pyridinyl]-4-piperidineacetic acid
M43875	2(1H)-Isoquinolineacetic acid, 6-(2,6-dioxo-3-piperidinyl)-3,4-dihydro-	2(1H)-Isoquinolineacetic acid, 6-(2,6-dioxo-3-piperidinyl)-3,4-dihydro-	Ligand for E3 Ligase
	2(1H)-Isoquinolineacetic acid, 6-(2,6-dioxo-3-piperidinyl)-3,4-dihydro-
M43882	1-(4-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidine-4-carbaldehyde	1-(4-(2,4-二氧代四氢嘧啶-1(2H)-基)苯基)哌啶-4-甲醛	Ligand for E3 Ligase
	4-Piperidinecarboxaldehyde, 1-[4-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-
	1-(4-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidine-4-carbaldehyde
M43884	1-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-4-piperidinecarboxylic acid	1-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-4-piperidinecarboxylic acid	Ligand for E3 Ligase
	1-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-4-piperidinecarboxylic acid
M43887	1-(5-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)pyridin-2-yl)piperidine-4-carbaldehyde	1-(5-(2,4-二氧代四氢嘧啶-1(2H)-基)吡啶-2-基)哌啶-4-甲醛	Ligand for E3 Ligase
	4-Piperidinecarboxaldehyde, 1-[5-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)-2-pyridinyl]-
	1-(5-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)pyridin-2-yl)piperidine-4-carbaldehyde
M43892	3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-fluorobenzoic acid	3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-fluorobenzoic acid	Ligand for E3 Ligase
	Benzoic acid, 4-fluoro-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)-
	3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-fluorobenzoic acid
M44119	Isonemerosin	(E)-alpha-(3,4-Methylenedioxybenzylidene)-beta-(3,4,5-trimethoxybenzyl)-gamma-butyrolactone	Others
	(E)-alpha-(3,4-Methylenedioxybenzylidene)-beta-(3,4,5-trimethoxybenzyl)-gamma-butyrolactone
M44596	11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid	11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid	Others
	11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid

信号通路

产品类型

AbMole

服务与支持

技术资源

联系我们